| Date | Location | Result | |
| 12/03/21 | Minneapolis, MN | Stanford 3, Iowa State 1 (25-19,23-25,25-18,25-17) | Box score |
| 11/20/21 | Waco, TX | Baylor 3, Iowa State 0 (25-19,25-18,25-19) | Box score |
| 11/19/21 | Waco, TX | Baylor 3, Iowa State 0 (25-19,25-17,25-19) | Box score |
| 11/13/21 | Ames, IA | Kansas St. 3, Iowa State 0 (25-23,25-13,25-23) | Box score |
| 11/11/21 | Ames, IA | Iowa State 3, Kansas St. 1 (25-21,23-25,25-20,25-17) | Box score |
| 11/06/21 | Norman, OK | Iowa State 3, Oklahoma 1 (25-16,22-25,27-25,25-17) | Box score |
| 11/05/21 | Norman, OK | Iowa State 3, Oklahoma 1 (23-25,25-15,25-18,25-17) | Box score |
| 10/31/21 | Ames, IA | West Virginia 3, Iowa State 1 (25-18,21-25,25-18,25-21) | Box score |
| 10/29/21 | Ames, IA | Iowa State 3, West Virginia 1 (25-21,25-20,21-25,26-24) | Box score |
| 10/22/21 | Ames, IA | Texas 3, Iowa State 0 (25-18,25-22,25-22) | Box score |
| 10/21/21 | Ames, IA | Texas 3, Iowa State 1 (24-26,25-16,25-14,25-12) | Box score |
| 10/08/21 | Lubbock, TX | Texas Tech 3, Iowa State 1 (25-22,25-23,21-25,25-22) | Box score |
| 10/07/21 | Lubbock, TX | Iowa State 3, Texas Tech 2 (21-25,25-20,25-23,24-26,19-17) | Box score |
| 10/02/21 | Lawrence, KS | Iowa State 3, Kansas 0 (25-20,25-20,25-20) | Box score |
| 10/01/21 | Lawrence, KS | Kansas 3, Iowa State 1 (26-28,25-16,25-19,25-20) | Box score |
| 09/25/21 | Ames, IA | Iowa State 3, TCU 2 (25-10,22-25,25-27,25-22,15-4) | Box score |
| 09/24/21 | Ames, IA | Iowa State 3, TCU 0 (25-21,25-18,25-24) | Box score |
| 09/18/21 | Minnesota 3, Iowa State 0 (25-17,25-19,25-20) | Box score | |
| 09/17/21 | Minneapolis, MN | Iowa State 3, St. Thomas (MN) 0 (25-12,26-24,25-15) | Box score |
| 09/15/21 | Cedar Falls, IA | Iowa State 3, UNI 0 (25-20,25-9,25-22) | Box score |
| 09/11/21 | Coralville, IA | Iowa 3, Iowa State 0 (25-20,25-19,25-21) | Box score |
| 09/10/21 | Coralville, IA | Iowa State 3, Syracuse 2 (20-25,25-21,22-25,25-19,15-11) | Box score |
| 09/10/21 | Coralville, IA | Iowa State 3, Ball St. 1 (26-24,18-25,25-19,25-13) | Box score |
| 09/04/21 | State College, PA | Iowa State 3, Oregon St. 0 (25-20,25-21,25-18) | Box score |
| 09/03/21 | State College, PA | Penn St. 3, Iowa State 0 (25-18,25-11,25-23) | Box score |
| 09/03/21 | State College, PA | Iowa State 3, LSU 1 (16-25,25-22,25-18,25-23) | Box score |
| 08/28/21 | Ames, IA | Iowa State 3, Omaha 0 (25-11,25-16,25-19) | Box score |
| 08/27/21 | Ames, IA | Iowa State 3, Drake 1 (25-20,25-20,23-25,25-17) | Box score |